Peripheral CHI3L1 expression is associated with APOE ε4 status in early-onset Alzheimer’s disease

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Peripheral CHI3L1 expression elevates in early-onset Alzheimer's disease, especially in APOE ε4 carriers.
Notable correlation was observed between CHI3L1 and LRP1 among individuals with mild cognitive impairment.
Assessment included biomarker-confirmed Alzheimer’s disease and healthy controls, revealing sex differences.
Findings support exploring CHI3L1 as a potential marker for genotype-linked inflammatory influences.

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Analysis reveals immune activation correlates with CHI3L1 in early-onset Alzheimer's, indicating inflammation's role in APOE ε4 carriers.

Lina Breit (2025) studied this question.

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Analysis reveals immune activation correlates with CHI3L1 in early-onset Alzheimer's, indicating inflammation's role in APOE ε4 carriers.