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November 20, 2025Diabetes CareOpen Access

The Role of Adaptive and Innovative Trial Designs in Diabetes Research: A Scoping Review

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Authors

AGAshni GoshraniRLRose LinLCLeonid Churilov

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Overview

This scoping review highlights adaptive trial designs in type 1 and type 2 diabetes, suggesting greater use may improve research outcomes.

Key Points

  • Adaptive trials demonstrate potential in diabetes, improving outcomes via innovative designs.
  • Identifying six key trials, including three in type 1 diabetes and one in type 2 diabetes, imparts critical insights.
  • Observational analysis across literature and clinical registries revealed current gaps in adaptive trial adoption.
  • This suggests a need for increased training and robust frameworks to promote these methodologies.

Cite This Study

Goshrani et al. (2025) studied this question.

synapsesocial.com/papers/6924f07ac0ce034ddc34fd3chttps://doi.org/10.2337/dc25-1508
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adaptive designs were primarily used but inadequately reported in early phase drug trials2024 · 1 citations
  2. 2Digital Twin Applications in Diabetes Management: Scoping Review2026 · 1 citations
  3. 3Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps2026
  4. 4Automated insulin delivery in type 2 diabetes: a meta-analysis of randomized trials protocol2026
  5. 5Understanding how the informed consent process influences the decision to participate in an adaptive platform trial: A scoping review2026