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November 20, 2025Frontiers in MicrobiologyOpen Access

Genomic dissection of the antimicrobial resistance epidemiology of Salmonella Typhimurium

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Authors

SKSandeep KaurSPSally R. PartridgeMPMichael Payne

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Overview

Genomic analysis reveals varied antimicrobial resistance in Salmonella Typhimurium, suggesting urgent need for surveillance.

Key Points

  • To analyze the antimicrobial resistance (AMR) patterns in Salmonella Typhimurium globally using genomic data.
  • Characterized ~65,000 Salmonella Typhimurium genomes using Multilevel Genome Typing (MGT)
  • Analyzed resistance patterns by MGT sequence type, geographic location, year, and source
  • Defined resistant MGT STs based on predicted resistance to antibiotics.
  • About 50% of STm isolates predicted resistant to at least one antibiotic
  • Identified 407 resistant MGT STs with significant geographic and temporal variation
  • Eight MGT STs classified as cefotaxime resistant; three as ciprofloxacin intermediate.

Cite This Study

Kaur et al. (2025) studied this question.

synapsesocial.com/papers/6924f07fc0ce034ddc34ffb7https://doi.org/10.3389/fmicb.2025.1683995
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