What question did this study set out to answer?

To characterize global trends and spatiotemporal distribution patterns of clinically critical antibiotic resistance in invasive Salmonella infections using longitudinal genomic data.

August 19, 2026Nature CommunicationsOpen Access

Global genomic surveillance uncovers emergence and spatiotemporal patterns of World Health Organization priority antibiotic resistance in invasive Salmonella

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YPYuhang Pei ZYZiru Yang XPXiaolu Pang

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Overview

Genomic epidemiology study uncovers rising resistance to critical antibiotics in invasive Salmonella isolates, highlighting the need for enhanced surveillance in underserved regions.

Key Points

To characterize global trends and spatiotemporal distribution patterns of clinically critical antibiotic resistance in invasive Salmonella infections using longitudinal genomic data.
Retrospective longitudinal genomic epidemiology analysis of 7,691 invasive Salmonella isolates collected between 1954 and 2024 from national surveillance and public datasets across 77 countries.
Evaluated resistance and decreased susceptibility profiles against World Health Organization priority antibiotics, including ciprofloxacin, third-generation cephalosporins (3GCs: ceftriaxone, cefixime), fourth-generation cephalosporins (4GCs), azithromycin, fosfomycin, and colistin.
Overall isolate resistance or decreased susceptibility rates were 7.39% for ciprofloxacin (identified in 29/77 [37.7%] countries) and 7.91% for 3GCs (ceftriaxone in 32.5% and cefixime in 37.7% of countries).
Isolate resistance rates were 4.23% for fosfomycin (15/77 [19.5%] countries), 0.79% for azithromycin (8/77 [10.4%] countries), and colistin resistance was detected in 10/77 (13.0%) countries.
Global temporal trends showed increasing resistance to azithromycin, ciprofloxacin, 3GCs, and 4GCs, alongside pronounced genomic surveillance gaps in African and South American regions.

Cite This Study

Pei et al. (2026) studied this question.

synapsesocial.com/papers/6a8563eb03308d306e2d7541 https://doi.org/10.1038/s41467-026-76354-1

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August 19, 2026Nature CommunicationsOpen Access

Global genomic surveillance uncovers emergence and spatiotemporal patterns of World Health Organization priority antibiotic resistance in invasive Salmonella

View Full Paper

Ask AI

Bookmark

Authors

YPYuhang Pei ZYZiru Yang XPXiaolu Pang

Discussion

Member takes

Overview

Genomic epidemiology study uncovers rising resistance to critical antibiotics in invasive Salmonella isolates, highlighting the need for enhanced surveillance in underserved regions.

Key Points

To characterize global trends and spatiotemporal distribution patterns of clinically critical antibiotic resistance in invasive Salmonella infections using longitudinal genomic data.
Retrospective longitudinal genomic epidemiology analysis of 7,691 invasive Salmonella isolates collected between 1954 and 2024 from national surveillance and public datasets across 77 countries.
Evaluated resistance and decreased susceptibility profiles against World Health Organization priority antibiotics, including ciprofloxacin, third-generation cephalosporins (3GCs: ceftriaxone, cefixime), fourth-generation cephalosporins (4GCs), azithromycin, fosfomycin, and colistin.
Overall isolate resistance or decreased susceptibility rates were 7.39% for ciprofloxacin (identified in 29/77 [37.7%] countries) and 7.91% for 3GCs (ceftriaxone in 32.5% and cefixime in 37.7% of countries).
Isolate resistance rates were 4.23% for fosfomycin (15/77 [19.5%] countries), 0.79% for azithromycin (8/77 [10.4%] countries), and colistin resistance was detected in 10/77 (13.0%) countries.
Global temporal trends showed increasing resistance to azithromycin, ciprofloxacin, 3GCs, and 4GCs, alongside pronounced genomic surveillance gaps in African and South American regions.

Cite This Study

Pei et al. (2026) studied this question.

synapsesocial.com/papers/6a8563eb03308d306e2d7541 https://doi.org/10.1038/s41467-026-76354-1

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