Identification of a Cu–OOH during the Cu–Aβ Reaction with Oxygen: Mechanistic Insights into Amyloid β Peptide Fibrillization in Alzheimer’s Disease

Wooyeol Ryu; Donghwa Lee; Sugyeong Hong; Jin Kim; Jihyeon Lee; Jeong Kyu Bang; Youngae Jung; Hyeon-Ju Kim; Sun Hee Kim

doi:10.1039/d5qi02016f

November 19, 2025Inorganic Chemistry Frontiers

Identification of a Cu–OOH during the Cu–Aβ Reaction with Oxygen: Mechanistic Insights into Amyloid β Peptide Fibrillization in Alzheimer’s Disease

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Key Points

Investigate the role of reactive intermediates in the Cu–Aβ reaction with oxygen and its implications for Alzheimer’s disease.
Analysis of the Cu–Aβ reaction with molecular oxygen
Identification of reactive intermediates formed during the reaction
Mechanistic exploration of Aβ peptide fibrillization
Identification of a Cu–OOH as a reactive intermediate
Insights into the mechanistic pathways of Aβ fibrillization
Establishment of the link between Cu–Aβ dynamics and Alzheimer’s pathology

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Implication

Mechanistic insights reveal how reactive intermediates from Cu–Aβ and Oxygen contribute to amyloid β fibrillization in Alzheimer’s disease, indicating potential targets for intervention.

Abstract

The reaction of copper-bound amyloid β (Cu–Aβ) with molecular oxygen is implicated in the fibrillization of Aβ peptides, a hallmark of Alzheimer’s disease pathology. Identifying reactive intermediates in the Cu–Aβ–O 2 ...

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Ryu et al. (2025) studied this question.

synapsesocial.com/papers/6924f095c0ce034ddc350c75 https://doi.org/10.1039/d5qi02016f

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Identification of a Cu–OOH during the Cu–Aβ Reaction with Oxygen: Mechanistic Insights into Amyloid β Peptide Fibrillization in Alzheimer’s Disease

Key Points

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Implication

Abstract

Discussion

Cite This Study

Identification of a Cu–OOH during the Cu–Aβ Reaction with Oxygen: Mechanistic Insights into Amyloid β Peptide Fibrillization in Alzheimer’s Disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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