Identification of Cu–OOH during the Cu–Aβ reaction with oxygen: mechanistic insights into amyloid β peptide fibrillization in Alzheimer's disease

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17 O ESEEM spectroscopy identifies the Cu–OOH intermediate formed during the Cu–Aβ–O 2 reaction with ascorbate. Integrated EPR and kinetic analyses elucidate the mechanisms of metal ion-mediated oxidative stress and amyloid fibrillization.