Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 19, 2025MicroorganismsOpen Access

COVID-19 is Associated with a Lipid Storm that Worsens in Cases of Severe Pneumonia

View Full Paper
Ask AI
Bookmark
Share

Authors

ABAmani BouabdallahMFMohamed Kacem Ben FradjMHMohamed Bessem Hammami

Discussion

Loading...

Member takes

Overview

Case–control study reveals lipid mediators imbalance in pneumonia cases, suggesting new metabolic pathways targeting.

Key Points

  • To investigate the lipidomic profile alterations in COVID-19 related pneumonia based on disease severity.
  • Case–control study of 135 hospitalized COVID-19 patients and 134 healthy individuals.
  • Analyzed selected polyunsaturated fatty acids, oxylipins, and endocannabinoids using liquid chromatography coupled to mass spectrometry.
  • Performed multivariate receiver operating characteristic curve-based model evaluation to define a lipidomic signature.
  • Identified increased levels of free polyunsaturated fatty acids, proinflammatory and pro-resolving oxylipins, and endocannabinoids in COVID-19 patients.
  • A combination of five lipid mediators accurately discriminates patients from controls with AUC of 0.977.
  • Severe pneumonia cases were characterized by an imbalance in oxylipins and elevated endocannabinoids.

Cite This Study

Bouabdallah et al. (2025) studied this question.

synapsesocial.com/papers/6924fed1c0ce034ddc350db6https://doi.org/10.3390/microorganisms13112622
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients2024 · 3 citations
  2. 2Lipidome is a valuable tool for the severity prediction of coronavirus disease 20192024 · 1 citations
  3. 3Polyunsaturated fatty acid-derived lipid mediator networks characterize COVID-19 severity and risk for critical illness2024 · 1 citations
  4. 4Effect of COVID-19 on lipid profile parameters and its correlation with acute phase reactants: A single-center retrospective analysis2022 · 16 citations
  5. 5Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study2022 · 26 citations