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December 5, 2022International Journal of Molecular SciencesOpen Access

Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study

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Authors

ÁAÁlvaro AparisiMMMarta Martín-FernándezCYCristina Ybarra-Falcón

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Overview

Prospective cohort study reveals linked oxidative stress and dyslipidemia in COVID-19 patients, suggesting lasting atherogenic risks.

Key Points

  • To evaluate the relationship between oxidative stress, lipid profile disruptions, and inflammatory markers during COVID-19 infection and through long-term recovery.
  • Prospective observational study evaluating acute COVID-19 patients against healthy controls, with long-term follow-up (IQR: 514 days).
  • Multivariate regression analysis assessed relationships between lipid peroxidation (LPO), lipid panels, and inflammatory cytokines.
  • Acute COVID-19 patients exhibited significantly reduced total cholesterol, LDL, and HDL alongside heightened oxidative stress and inflammatory responses relative to healthy controls.
  • Lipid peroxidation significantly associated with total cholesterol (OR: 0.982; 95% CI: 0.969–0.996; p = 0.012), IL1-RA (OR: 0.999; 95% CI: 0.998–0.999; p = 0.021), IL-6 (OR: 1.062; 95% CI: 1.017–1.110; p = 0.007), IL-7 (OR: 0.653; 95% CI: 0.433–0.986; p = 0.042), and IL-17 (OR: 1.098; 95% CI: 1.010–1.193; p = 0.028).
  • Although overall lipid abnormalities improved over follow-up (IQR: 514 days), patients presenting with high admission lipid peroxidation maintained an atherogenic lipid profile.

Cite This Study

Aparisi et al. (2022) studied this question.

synapsesocial.com/papers/6a727d156c240de38cdc65cfhttps://doi.org/10.3390/ijms232315350
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Also Consider

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  1. 1Oxidative Stress and Lipid Profile during Acute Phase of COVID-19 Infection and after Recovery: Evidence of a Sequel in LDL2023 · 1 citations
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  4. 4Effect of COVID-19 on lipid profile parameters and its correlation with acute phase reactants: A single-center retrospective analysis2022 · 16 citations
  5. 5COVID-19 is Associated with a Lipid Storm that Worsens in Cases of Severe Pneumonia2025