What does this research mean for the field?

Patients recovered from COVID-19 exhibit significantly higher proportions of large, less atherogenic LDL particles compared to acute COVID-19 patients, though persistent oxidative alterations in LDL quality remain six months post-infection. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 4, 2023Open Access

Oxidative Stress and Lipid Profile during Acute Phase of COVID-19 Infection and after Recovery: Evidence of a Sequel in LDL

Q: What are the key findings of this study?

Patients recovered from COVID-19 for six months had significantly higher numbers of large, less atherogenic LDL particles compared to those with acute infection (P<0.05).

Q: What is the clinical evidence from this study?

Study design: Observational. Population: COVID-19 (n=63). Intervention: Acute COVID-19 infection vs. Recovered COVID-19 (six months post-infection). Primary outcome: Number of large LDL particles (p=<0.05).

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Key result

Six-month COVID-19 recovery linked to more large, less atherogenic LDL particles versus acute infection.

P<0.05
n=63

Why the study?

This study aimed to investigate the atherogenicity and quality of LDL particles in patients with acute COVID-19 infection and those recovered from it.

Population

Adults aged 18 years or older with acute COVID-19 (n=33) or recovered from COVID-19 (n=30)

Comparison

Acute COVID-19 group vs Recovered COVID-19 group

Authors

ZLZahra Lotfollahi LNLuana dos S. Neres AMAndressa F. Mathias

Discussion

Member takes

Overview

May signal heightened CV risk in COVID-19 survivors; hypothesis-generating and requires prospective validation before clinical adoption.

Study Design

Type

Observational (n=63)

Structured PICO

Population

63 adults aged ≥18 years, comprising 33 with acute COVID-19 and 30 evaluated six months post-recovery, assessed for LDL particle atherogenicity.

Outcome

Atherogenicity (quality) of LDL particles evaluated using Z-scan, UV-visible spectroscopy, and Lipoprintsurrogate

Main Result

p-value: p=<0.05

COVID-19 infection is associated with oxidative modification and increased atherogenicity of LDL particles, which persists as a sequel even six months after recovery.

Cite This Study

Lotfollahi et al. (2023) conducted an observational in COVID-19 (n=63). Acute COVID-19 infection vs. Recovered COVID-19 (six months post-infection) was evaluated on Number of large LDL particles (p=<0.05). Patients recovered from COVID-19 for six months had significantly higher numbers of large, less atherogenic LDL particles compared to those with acute infection (P<0.05).

synapsesocial.com/papers/6aaa0d2d788c57f1c6a4e6ef https://doi.org/10.20944/preprints202308.0388.v1

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August 4, 2023Open Access

Oxidative Stress and Lipid Profile during Acute Phase of COVID-19 Infection and after Recovery: Evidence of a Sequel in LDL

View Full Paper

Ask AI

Bookmark

Key result

Six-month COVID-19 recovery linked to more large, less atherogenic LDL particles versus acute infection.

P<0.05
n=63

Why the study?

This study aimed to investigate the atherogenicity and quality of LDL particles in patients with acute COVID-19 infection and those recovered from it.

Population

Adults aged 18 years or older with acute COVID-19 (n=33) or recovered from COVID-19 (n=30)

Comparison

Acute COVID-19 group vs Recovered COVID-19 group

Authors

ZLZahra Lotfollahi LNLuana dos S. Neres AMAndressa F. Mathias

Discussion

Member takes

Overview

May signal heightened CV risk in COVID-19 survivors; hypothesis-generating and requires prospective validation before clinical adoption.

Study Design

Type

Observational (n=63)

Structured PICO

Population

63 adults aged ≥18 years, comprising 33 with acute COVID-19 and 30 evaluated six months post-recovery, assessed for LDL particle atherogenicity.

Outcome

Atherogenicity (quality) of LDL particles evaluated using Z-scan, UV-visible spectroscopy, and Lipoprintsurrogate

Main Result

p-value: p=<0.05

COVID-19 infection is associated with oxidative modification and increased atherogenicity of LDL particles, which persists as a sequel even six months after recovery.

Cite This Study

synapsesocial.com/papers/6aaa0d2d788c57f1c6a4e6ef https://doi.org/10.20944/preprints202308.0388.v1

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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