Smart bioactive hydrogels for myocardial infarction repair: a multifunctional approach integrating stimuli-responsive drug delivery, electroconductivity, and real-time biosensing
This review demonstrates how smart bioactive hydrogels improve cardiac repair in myocardial infarction, highlighting drug delivery and biosensing capabilities.
Key Points
This review evaluates the multifunctional roles of smart bioactive hydrogels in repairing myocardial infarction.
Narrative review of recent advances in smart hydrogels for myocardial infarction repair.
Literature search in PubMed, Scopus, Web of Science, and Google Scholar from 2010 to 2025.
Focus on hydrogels integrating stimuli-responsive drug delivery, electroconductivity, and biosensing technologies.
Smart bioactive hydrogels reduced infarct size by 20–45% and increased neovascular density by 1.5–2.3-fold in preclinical models.
Conductive materials like graphene oxide improved left ventricular ejection fraction by 8–15% and reduced QRS duration by ~15 ms.
Real-time biosensing allowed monitoring of biochemical cues, maintaining stable signals for up to 4 weeks.