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November 30, 2025Organic Chemistry Frontiers2 citations

DBU-Promoted 4+3 Annulation of Pyrrole-2-carbaldehyde Derivatives with Indene-2carbaldehydes: Synthesis of Indene-Fused Pyrrolo1,2-aazepines

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LCLi Jia ChenYHYong-Yu HeYWYu Qing Wang

Key Points

  • Indene-fused pyrrolo[1,2-a]azepines were synthesized successfully using the developed method.
  • The reaction demonstrated a broad substrate scope and proceeded under mild conditions.
  • This strategy utilizes base-promoted [4+3] annulation for effective synthesis of complex compounds.
  • Results highlight the potential for further applications in organic synthesis.

Abstract

A base-promoted 4+3 annulation of pyrrole-2-carbaldehydes with indene-2-carbaldehydes for synthesizing indene-fused pyrrolo1,2-aazepines has been developed. The reaction proceeds under mild conditions and demonstrates a remarkably broad substrate scope, accommodating a...

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/692b94261d383f2b2a37838bhttps://doi.org/10.1039/d5qo01433f
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