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November 26, 2025Organic Chemistry Frontiers

DBU-Promoted [4+3] Annulation of Pyrrole-2-carbaldehyde Derivatives with Indene-2carbaldehydes: Synthesis of Indene-Fused Pyrrolo[1,2-a]azepines

Li Jia Chen Yong-Yu He Yu-Qing Wang Lin Liu Jun Ying Jin-Bao Peng

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Abstract

A base-promoted [4+3] annulation of pyrrole-2-carbaldehydes with indene-2-carbaldehydes for synthesizing indene-fused pyrrolo[1,2-a]azepines has been developed. The reaction proceeds under mild conditions and demonstrates a remarkably broad substrate scope, accommodating a...

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Chen et al. (2025) studied this question.

synapsesocial.com/papers/694035ec2d562116f2908e44 https://doi.org/10.1039/d5qo01433f

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