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December 5, 2025Nucleic Acids ResearchOpen Access

Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences

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Analysis reveals intermolecular interactions of G-quadruplex structures in gene expression, suggesting new regulatory mechanisms.

G-quadruplex structures impact gene expression through intermolecular interactions, and can facilitate chromatin remodeling.
Key findings indicate primary sequence interactions govern G4/G4 interactions in vitro, emphasizing sequence specificity.
An experimental approach was utilized to evaluate intermolecular interactions between G-quadruplexes under various conditions.
These findings highlight the potential regulatory role of G4 structures in cellular mechanisms, warranting further investigation.

Xia et al. (2025) studied this question.

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December 5, 2025Nucleic Acids ResearchOpen Access

View Full Paper

Ask AI

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Authors

Analysis reveals intermolecular interactions of G-quadruplex structures in gene expression, suggesting new regulatory mechanisms.

G-quadruplex structures impact gene expression through intermolecular interactions, and can facilitate chromatin remodeling.
Key findings indicate primary sequence interactions govern G4/G4 interactions in vitro, emphasizing sequence specificity.
An experimental approach was utilized to evaluate intermolecular interactions between G-quadruplexes under various conditions.
These findings highlight the potential regulatory role of G4 structures in cellular mechanisms, warranting further investigation.

Xia et al. (2025) studied this question.

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