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December 8, 2025Molecular Medicine ReportsOpen Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

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Authors

QMQuwu MushuoJLJianchun LiQHQiongdan Hu

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Overview

Review highlights mitophagy's role in oxidative stress and inflammation in chronic kidney disease, suggesting therapeutic strategies to combat fibrosis.

Key Points

  • Chronic kidney disease progression is driven by oxidative stress and impaired mitophagy, leading to persistent inflammation.
  • The review emphasizes the critical molecular mechanisms governing mitophagy and its disruption in chronic kidney disease.
  • Mitophagy plays a key role in ROS production and inflammation, contributing to the progression of fibrosis in kidney disease.
  • Emerging therapeutic strategies aim to enhance antioxidant capacity and restore mitophagy, suggesting new avenues for treatment.

Cite This Study

Mushuo et al. (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236c8bdhttps://doi.org/10.3892/mmr.2025.13771
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease: From Molecular Mechanisms to Biomarkers and Targeted Therapies2026
  2. 2The role of mitophagy in the development of chronic kidney disease2024 · 8 citations
  3. 3Development of mitochondrial dysfunction and oxidative stress in chronic kidney disease2024 · 3 citations
  4. 4Redox-Mediated Mitochondrial Dysfunction as a Common Pathogenic Axis in Acute Kidney Injury and Chronic Kidney Disease2026
  5. 5The Mechanisms and Treatment Approaches of Oxidative Stress andInflammation in the Development of Chronic Kidney Disease2026