What question did this study set out to answer?

Evaluate the pathogenic mechanisms of mitochondrial dysfunction and oxidative stress in promoting the onset and progression of chronic kidney disease.

January 1, 2024European Journal of InflammationOpen Access

Development of mitochondrial dysfunction and oxidative stress in chronic kidney disease

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Authors

ABAlexander V. BlagovResearch Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences VOVarvara A. OrekhovaResearch Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences AZAlexander D. ZhuravlevResearch Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences

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Implication

Review highlights the interplay between mitochondrial dysfunction and oxidative stress in renal cells, suggesting new therapeutic targets for slowing chronic kidney disease progression.

Key Points

Evaluate the pathogenic mechanisms of mitochondrial dysfunction and oxidative stress in promoting the onset and progression of chronic kidney disease.
Narrative review evaluating literature on cellular bioenergetics and mitochondrial integrity in chronic renal pathology.
Analysis focused on the metabolic vulnerability of renal cells, particularly proximal tubule epithelial cells, under conditions of oxidative injury.
Mitochondrial structural and functional breakdown deprives energy-intensive proximal tubule cells of adenosine triphosphate, impairing vital solute transport.
Excessive mitochondrial reactive oxygen species drive sustained oxidative stress, initiating a self-amplifying cycle that accelerates nephron damage and tissue fibrosis.

Cite This Study

Blagov et al. (2024) studied this question.

synapsesocial.com/papers/6a82a9befdcaa17bff6d08d6 https://doi.org/10.1177/1721727x241227349

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Implication

Review highlights the interplay between mitochondrial dysfunction and oxidative stress in renal cells, suggesting new therapeutic targets for slowing chronic kidney disease progression.

Development of mitochondrial dysfunction and oxidative stress in chronic kidney disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Development of mitochondrial dysfunction and oxidative stress in chronic kidney disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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