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August 9, 2026BiomoleculesOpen Access

Redox-Mediated Mitochondrial Dysfunction as a Common Pathogenic Axis in Acute Kidney Injury and Chronic Kidney Disease

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Authors

EMEwelina MłynarskaKBKinga BojdoKHKatarzyna Hossa

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Overview

Review discusses the role of mitochondrial dysfunction in kidney diseases, suggesting new therapeutic targets.

Key Points

  • The review aims to summarize the shared mechanisms of redox imbalance and mitochondrial dysfunction in kidney diseases.
  • Summarized evidence from experimental and clinical studies
  • Analyzed mechanisms such as ROS production, NAD+ metabolism, mitochondrial dynamics, and quality control pathways.
  • Discussed emerging biomarkers and therapeutic strategies.
  • Mitochondrial dysfunction contributes to inflammation, fibrosis, apoptosis, and maladaptive repair in kidney disease.
  • Excessive ROS production and impaired NAD+ metabolism are key factors in disease progression.
  • Therapeutic strategies targeting oxidative stress and mitochondrial dysfunction are emerging as potential interventions.

Cite This Study

Młynarska et al. (2026) studied this question.

synapsesocial.com/papers/6a782d4e2e1896536c8403c9https://doi.org/10.3390/biom16081148
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease: From Molecular Mechanisms to Biomarkers and Targeted Therapies2026
  2. 2Integrative Insights Into Mitochondrial Dysfunction and Organelle Crosstalk in Diabetic Kidney Disease2026 · 5 citations
  3. 3Mitophagy and oxidative stress in chronic kidney disease (Review)2025
  4. 4Mitochondrial redox imbalance in triggering regulated cell death in kidney diseases2026 · 1 citations
  5. 5Molecular Basis of Oxidative Stress-Induced Acute Kidney Injury, Kidney Fibrosis, Chronic Kidney Disease, and Clinical Significance of Targeting Reactive Oxygen Species-Regulated Pathways to Treat Kidney Disease2025