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December 8, 2025BloodOpen Access

Incidence burden of AML across the US and Puerto Rico: A two-decade analysis of trends and disparities (1999-2021)

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Authors

NANouman Aziz

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Overview

Population-based analysis reveals rising AML incidence trends in the US and Puerto Rico, indicating disparities across urbanization and racial groups.

Key Points

  • To analyze the incidence burden and demographic disparities of acute myeloid leukemia in the US and Puerto Rico over two decades.
  • Retrospective population-based analysis using CDC WONDER Database
  • Calculated age-adjusted incidence rates per 100,000 population
  • Trend analysis using Joinpoint regression for annual percentage changes
  • Subgroup analyses based on age, sex, race/ethnicity, geographic region, and urbanization
  • Overall AML incidence showed a modest increase with an AAPC of +0.49% from 1999 to 2021
  • Significant rise in the South with AAPC of +0.76%; other regions showed non-significant changes
  • Increase in incidence noted among adolescents and older age groups, particularly those aged 85+
  • Racial disparities prevalent, with American Indian/Alaska Natives showing the highest increase in AML incidence

Cite This Study

Nouman Aziz (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d13dhttps://doi.org/10.1182/blood-2025-4435
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Demographics and trends of acute myeloid leukemia among young adults in the United States and Puerto Rico, 1999-2021.2026
  2. 2Changing burden of Acute Myeloid Leukemia in the United States: A 23-year national analysis2025
  3. 3Acute Myeloid Leukemia mortality in u.S. older adults: A 45-year nationwide analysis with forecasting through 20502025
  4. 4Comparative analysis of mortality trends in acute versus chronic myeloid leukemia in the U.S. population with time series projection: A CDC WONDER–based study (1999–2023).2026
  5. 5Comparative trends in mortality from acute lymphoblastic and Acute Myeloid Leukemia in the United States: A CDC wonder analysis (1999–2020)2025