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December 8, 2025BloodOpen Access

Second autologous transplantation remains a valid consolidation option in patients with relapsed multiple myeloma: A report from the Latin American bone marrow transplantation group

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Authors

GRGuillermina RemaggiMBMariano BerroARAlejandra Rocca

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Overview

Retrospective analysis shows improved progression-free survival in relapsed multiple myeloma patients undergoing autologous transplantation, indicating that it remains a viable treatment option.

Key Points

  • To evaluate the effectiveness of second autologous transplantation in improving progression-free survival for patients with relapsed multiple myeloma.
  • Conducted a retrospective analysis of patients with relapsed multiple myeloma who underwent autologous transplantation.
  • Analyzed data from thirteen transplant centers in Latin American countries.
  • Assessed outcomes including progression-free survival and response rates post-transplant.
  • Four-year progression-free survival was 31.2% with a median follow-up of 48 months.
  • Patients demonstrated varied responses, with a complete response rate of 37% by day +100 post-transplant.
  • Extramedullary disease and lenalidomide-refractory status were associated with significantly shorter progression-free survival.

Cite This Study

Remaggi et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d18ehttps://doi.org/10.1182/blood-2025-5839
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Second autologous hematopoietic stem cell transplantation in multiple myeloma2026
  2. 2Salvage or Second Autologous SCT in Relapsed Multiple Myeloma (2016–2026): A Decade in Review2026 · 1 citations
  3. 3Impact of second autologous stem‐cell transplantation at relapsed multiple myeloma: A French multicentric real‐life study2024 · 4 citations
  4. 4The efficacy and safety of second salvage autologous transplantation in myeloma patients2024 · 6 citations
  5. 5Good report of secondary allogeneic hematopoietic stem cell transplantation in patients with refractory/relapsed Acute Myeloid Leukemia2025