What type of study is this?

This is a Human Clinical Trial study (also classified as: Systematic Review).

What question did this study set out to answer?

Assess variability in reporting practices of clinical trial results for myelodysplastic syndromes (MDS).

December 8, 2025BloodOpen Access

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Systematic review highlights inconsistent response criteria in clinical trials for myelodysplastic syndromes, suggesting need for standardization.

Assess variability in reporting practices of clinical trial results for myelodysplastic syndromes (MDS).
Systematic review of clinical trials registered on ClinicalTrials.gov for MDS from 2015 to 2024.
Included trials focused on adults with MDS and reported results, with specific exclusion criteria.
Categorized trials by disease risk (lower-risk vs higher-risk) and trial phase (early phase vs late phase).
Identified 502 MDS trials, with 72 trials analyzed based on inclusion criteria.
Baseline characteristics reported frequently included age (100%), disease risk (74%), and blood counts.
Notably variable reporting of endpoints, response criteria, and definitions hinder clarity and efficacy assessments.

Pugh et al. (2025) studied this question.

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Systematic review highlights inconsistent response criteria in clinical trials for myelodysplastic syndromes, suggesting need for standardization.