What type of study is this?

This is a Human Clinical Trial study.

What question did this study set out to answer?

Evaluate the effect of clinical trial enrollment on survival and identify barriers impacting participation in patients with MDS and CMML.

December 8, 2025BloodOpen Access

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Retrospective analysis shows improved survival in MDS patients enrolled in clinical trials, highlighting barriers to participation.

Evaluate the effect of clinical trial enrollment on survival and identify barriers impacting participation in patients with MDS and CMML.
Retrospective evaluation of patients with MDS or CMML at a cancer center
Assessed clinical characteristics and bone marrow data during screening
Analyzed overall survival using Kaplan-Meier method with log-rank test and multivariable analysis using Cox model
593 patients screened for trials; 233 (39%) treated on protocol, 360 (61%) screen failures
Median overall survival for clinical trial enrollees was 67.4 months from diagnosis
Patients with HMA failure showed improved overall survival when treated on trials compared to those not enrolled

Hendrickson et al. (2025) studied this question.

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