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December 8, 2025BloodOpen Access

Temporal trends in overall survival among patients with high-risk MDS: Insights from the spanish MDS registry (RESMD)

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Authors

APAna Alfonso PiérolaMAMontserrat ArnánBXBlanca Xicoy

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Overview

Observational analysis shows improved overall survival in high-risk MDS patients, suggesting therapeutic advances may be effective.

Key Points

  • To evaluate temporal trends in overall survival among patients with high-risk MDS using registry data.
  • Included high-risk MDS patients recorded in the Spanish Registry (2000-2024)
  • Survival calculated from diagnosis to death or last follow-up
  • Patients stratified by diagnosis period into quinquennia
  • Used Kaplan–Meier curves and log-rank tests for analysis
  • Applied multivariable Cox regression to assess survival trends adjusting for age and IPSS-R risk group.
  • 4002 patients with high-risk MDS included in the analysis
  • Median age at diagnosis increased from 66.6 years to 72.3 years from 2000-2004 to 2020-present
  • Significant increase in use of hypomethylating agents from 1.3% to 35.6%
  • Median overall survival varied but showed no significant changes until adjustments for age and IPSS-R were made
  • Younger patient cohorts diagnosed more recently displayed significantly better survival outcomes.

Cite This Study

Piérola et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d835https://doi.org/10.1182/blood-2025-3868
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