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December 8, 2025Blood

Patient outcomes for sickle cell disease with support staff-driven interventions: A scoping review

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Authors

SGShenise GilyardAPAmie Patel

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Overview

Scoping review reveals community health workers' involvement likely improves health maintenance in sickle cell disease care, suggesting a need for multidisciplinary support teams.

Key Points

  • To summarize existing evidence on the impact of ambulatory support staff on patient outcomes in sickle cell disease care.
  • Reviewed literature on sickle cell disease and support interventions from PubMed, Embase, and PsycINFO (2005-2025).
  • Included peer-reviewed articles focusing on patient outcomes from non-physician outpatient interventions.
  • Selected 9 studies evaluating healthcare utilization, medication adherence, and health maintenance screening.
  • Out of 9 studies, 5 were randomized controlled trials (RCTs) and 4 were observational studies.
  • Most RCTs did not show significant improvement in hydroxyurea adherence or acute care utilization.
  • Observational studies indicated improvements in health maintenance screening and clinic follow-up with support staff intervention.

Cite This Study

Gilyard et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d942https://doi.org/10.1182/blood-2025-7892
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Implementation of a comprehensive sickle cell center leads to improved access to care and decreased acute care use2026
  2. 2The role of palliative care in sickle cell disease: A single database literature review of contemporary outcomes data2025
  3. 3Community Health Worker–Integrated Model for Sickle Cell Disease Management: Protocol for a Feasibility Study2026
  4. 4Consolidation of adult inpatient sickle cell care to improve patients' and learners' experiences: A qualitative exploration of various stakeholders' perspectives2025
  5. 5A mixed-methods evaluation to optimize the existing hospital based sickle cell disease care model from a tribal area of Gujarat, India2026