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December 8, 2025BloodOpen Access

Venous thromboembolism and bleeding rates in pregnant and postpartum patients with sickle cell disease

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Authors

SASharl AzarEKElizabeth S. KlingsDSDeborah Siegal

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Overview

Retrospective cohort reveals high VTE and bleeding rates in postpartum sickle cell disease patients, suggesting need for thromboprophylaxis.

Key Points

  • To determine rates of venous thromboembolism (VTE), bleeding, and thromboprophylaxis use in pregnant and postpartum patients with sickle cell disease (SCD).
  • IRB-approved retrospective cohort study at Mass General Brigham hospital system from 2015 to 2025.
  • Examined medical records of patients with SCD and one or more pregnancies.
  • Analyzed demographics, medication use, lab data, and VTE and bleeding events during pregnancy and postpartum.
  • VTE occurred in 17% of pregnancies; 90% of events included pulmonary embolism.
  • Postpartum hemorrhage (EBL ≥1000mL) occurred in 20% of deliveries.
  • Thromboprophylaxis was prescribed in only 15% of pregnancies, primarily due to prior VTE history.

Cite This Study

Azar et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d98ehttps://doi.org/10.1182/blood-2025-2947
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes associated with mitigating venous thromboembolism risk in pregnant patients with sickle cell disease2025
  2. 2Increased risk of venous thromboembolism and hypertensive disorders during pregnancy in sickle cell disease patients: A meta-analysis focused on actionable outcomes2025
  3. 3Pregnancy related complications and placenta pathology in pregnant women with sickle cell disease2025 · 1 citations
  4. 4High rates of severe maternal morbidity and preterm birth among pregnant individuals with sickle cell disease, a nationwide study from 2020-20242025
  5. 5Retrospective Analysis of Transfusions on Sickle Cell–Related Morbidity in Pregnancy2024