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December 8, 2025BloodOpen Access

High rates of severe maternal morbidity and preterm birth among pregnant individuals with sickle cell disease, a nationwide study from 2020-2024

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Authors

KDKevin DysartMontreal Neurological Institute and Hospital

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Overview

Nationwide study reports elevated severe maternal morbidity and preterm birth in patients with sickle cell disease, highlighting significant health disparities.

Key Points

  • This research aims to evaluate severe maternal morbidity and preterm birth outcomes in pregnant patients with sickle cell disease using contemporary health data.
  • Conducted a retrospective cohort study using the Epic Cosmos electronic health record database.
  • Analyzed delivery encounters from 2020-2024 for pregnant individuals with sickle cell disease.
  • Defined severe maternal morbidity using the CDC algorithm, excluding sickle cell crisis and transfusion effects.
  • Identified 2,679 deliveries among individuals with sickle cell disease, showing a 25% incidence of severe maternal morbidity.
  • Adjusted odds of severe maternal morbidity were 8.67 times higher in sickle cell disease patients, reducing to 4.61 when excluding specific criteria.
  • Found that the adjusted odds of preterm birth were 1.66 times higher for patients with sickle cell disease compared to those without.

Cite This Study

Kevin Dysart (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfc2https://doi.org/10.1182/blood-2025-177
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pregnancy outcomes among women with sickle cell disease: A propensity score-matched analysis approach using the national inpatient sample (2017-2022)2025
  2. 2Increased risk of venous thromboembolism and hypertensive disorders during pregnancy in sickle cell disease patients: A meta-analysis focused on actionable outcomes2025
  3. 3Cardiopulmonary complications during pregnancy as a risk factor for cesarean delivery in a two center, sickle cell disease pregnancy cohort2025
  4. 4Severe maternal morbidity according to sickle cell disease genotype2026
  5. 5Pregnancy related complications and placenta pathology in pregnant women with sickle cell disease2025 · 1 citations