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December 8, 2025BloodOpen Access

Understanding the impact of chronic red blood cell transfusion on day-to-day functioning in sickle cell disease (SCD): A mixed methods study of pediatric and adult experience

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Authors

COChinonso OnuohaPMPaul MihasMBMarcella H. Boynton

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Overview

Mixed-methods study shows chronic transfusion may worsen pain and fatigue in pediatric and adult sickle cell disease patients, indicating a need for patient-centered interventions.

Key Points

  • This study aimed to assess the symptom and procedural burden of chronic red blood cell transfusion in individuals with sickle cell disease.
  • Conducted a mixed-methods study in pediatric and adult patients with sickle cell disease receiving chronic transfusion.
  • Collected quantitative data using ASCQ-Me and PedsQL instruments for adult and pediatric participants.
  • Performed semi-structured interviews to gather qualitative data on patient experiences and burdens.
  • Analyzed quantitative data descriptively and qualitative data thematically using MAXQDA software.
  • 20 participants had surveys completed on transfusion day, with adults reporting high pain and stiffness levels.
  • Qualitative themes included fatigue patterns, complications from vascular access, and the impact on schooling and work.
  • Adults showed low health-related quality of life scores compared to reference populations, while pediatric patients reported better outcomes.

Cite This Study

Onuoha et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d98fhttps://doi.org/10.1182/blood-2025-2949
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews2026
  2. 2Heart rate changes in chronically red cell transfusion‐dependent patients—A dose‐dependent effect of red cell transfusion: A randomized cross‐over trial, interim analysis2025
  3. 3A global survey of blood transfusion practices for patients with sickle cell disease2026
  4. 4Real-World Effectiveness and Resource Utilization of Red Blood Cell Exchange in Adult Sickle Cell Disease: a Nationwide Robust Analysis from 2017-20222025
  5. 5Cerebral hemodynamic response to chronic transfusion is associated with cerebral vasculopathy in sickle cell anemia2025