December 8, 2025BloodOpen Access

Clinical outcomes associated with conditioning regimens in patients with primary central nervous system lymphoma undergoing consolidation autologous stem cell transplantation

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To compare clinical outcomes of different conditioning regimens in patients with primary central nervous system lymphoma undergoing consolidation autologous stem cell transplantation.
Retrospective study of 160 newly diagnosed PCNSL patients
Evaluation of various conditioning regimens: thiotepa/busulfan/cyclophosphamide, busulfan/thiotepa, and non-thiotepa
Analysis of progression-free survival, overall survival, nonrelapse mortality, and treatment-related toxicities
BuTT and TBC conditioning regimens showed comparable 3-year progression-free survival rates (83.6% vs 80.3%)
Non-thiotepa conditioning regimens were associated with significantly worse survival outcomes (3-year PFS: 46.4%)
Thioteppa-based regimens demonstrated better safety profiles with lower infection rates compared to non-thiotepa

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Implication

Retrospective analysis reveals superior outcomes for thiotepa-containing regimens in consolidation autologous stem cell transplantation for PCNSL, highlighting safety differences.

Cite This Study

Cho et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de24 https://doi.org/10.1182/blood-2025-5455

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Implication

Retrospective analysis reveals superior outcomes for thiotepa-containing regimens in consolidation autologous stem cell transplantation for PCNSL, highlighting safety differences.

Clinical outcomes associated with conditioning regimens in patients with primary central nervous system lymphoma undergoing consolidation autologous stem cell transplantation

Key Points

Discussion

Implication

Cite This Study

Clinical outcomes associated with conditioning regimens in patients with primary central nervous system lymphoma undergoing consolidation autologous stem cell transplantation

Key Points

Discussion

Implication

Cite This Study

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