What question did this study set out to answer?

This analysis aimed to evaluate various consolidation strategies following induction chemotherapy in patients with PCNSL.

December 8, 2025BloodOpen Access

Comparative analysis of consolidation strategies after induction chemotherapy in primary central nervous system lymphoma

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This analysis aimed to evaluate various consolidation strategies following induction chemotherapy in patients with PCNSL.
Retrospective analysis of 394 newly diagnosed PCNSL patients from Asan Medical Center (2000-2023).
Patients received high-dose methotrexate-based induction and were categorized into different consolidation strategies.
Survival outcomes were analyzed using Kaplan–Meier method and multivariable Cox regression.
HDC-ASCT showed a significantly better 2-year PFS rate of 76.1% and OS rate of 83.6% versus observation (31.8% PFS, 51.3% OS).
For elderly patients, HDC-ASCT was the only effective strategy with superior PFS (73.4%) and OS (76.4%) rates.
No significant survival benefit was observed for reduced-intensity chemotherapy or whole brain radiotherapy compared to observation.

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Retrospective analysis reveals improved progression-free survival in elderly patients with PCNSL receiving induction chemotherapy and whole brain radiotherapy, suggesting limited effectiveness of some

Cite This Study

Hyung et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de28 https://doi.org/10.1182/blood-2025-5457

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Comparative analysis of consolidation strategies after induction chemotherapy in primary central nervous system lymphoma

Key Points

Discussion

Implication

Cite This Study

Comparative analysis of consolidation strategies after induction chemotherapy in primary central nervous system lymphoma

Key Points

Discussion

Implication

Cite This Study

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