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December 8, 2025Blood

The ‘αO2-PRBCThal’ trial on the use of hemanext One® for blood transfusion support transfusion-dependent thalassemia

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Authors

KSKonstantinos StamoulisHellenic Aerospace Industry (Greece)AAAlkmini T. AnastasiadiUniversity of PatrasPFPagona FlevariLaiko General Hospital of Athens

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Implication

Open-label trial shows safety and efficacy of HEMANEXT ONE for RBC storage in transfusion-dependent thalassemia, suggesting potential benefits over standard methods.

Key Points

  • The study aims to evaluate the non-inferiority of HEMANEXT ONE RBC storage compared to standard methods in transfusion-dependent thalassemia patients.
  • Open-label, observational study
  • Includes adult patients with documented β-TDT
  • Assessment of storage effects on transfusion burden and hemolysis
  • Comparison of RBCs stored under hypoxic conditions vs standard methods
  • Trial targets enrollment of at least 26 evaluable patients
  • Initial enrollment began in April 2025
  • Both sites are located in Greece
  • Suggests advantages of hypoxic storage in reducing oxidative stress

Cite This Study

Stamoulis et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e316https://doi.org/10.1182/blood-2025-8224
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Clinical Investigation of Hypoxic Red Blood Cell Administration in Patients with Transfusion-Dependent Hematological Malignancies and Burns2026
  2. 2All 19 subjects with transfusion-dependent β-thalassemia achieved transfusion independence after treatment with RM-001 (autologous HBG1/2 promoter-modified CD34+ hematopoietic stem and progenitor cells)2025
  3. 3Novel Red Blood Cell Exchange Parameters for Treatment of Transfusion-Dependent Thalassemia Based on Experience of Five Patients2025 · 2 citations
  4. 4Oxidative Stress and Antioxidant Status in Adult Patients with Transfusion-Dependent Thalassemia: Correlation with Demographic, Laboratory, and Clinical Biomarkers2024 · 9 citations
  5. 5Haploidentical haematopoietic stem cell transplantation for thalassaemia major: A phase IV , open‐label, single‐centre trial2026