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This research examines the outcomes of patients with sickle cell trait hospitalized due to preeclampsia and eclampsia.

December 8, 2025BloodOpen Access

Maternal outcomes in sickle cell trait patients hospitalized with preeclampsia and eclampsia

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AAAmro AwadHennepin County Medical Center

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Implication

Retrospective assessment reveals sickle cell trait increases postpartum hemorrhage and acute kidney injury in pre-eclamptic women, implying greater healthcare utilization.

Key Points

This research examines the outcomes of patients with sickle cell trait hospitalized due to preeclampsia and eclampsia.
Retrospective assessment using National Inpatient Sample (NIS) databases from 2016-2021.
Identification of hospital admissions with preeclampsia and eclampsia using ICD codes.
Comparison of hospital characteristics and outcomes between patients with and without sickle cell trait.
Utilization of statistical tests for analyzing outcomes, such as Chi-square and t-tests.
Out of 1,129,400 hospitalizations, 9,050 (0.8%) had sickle cell trait.
Patients with sickle cell trait experienced higher rates of postpartum hemorrhage (8.6% vs 7.2%) and acute kidney injury (201.8 vs 9,186 per 1.12 million).
Hospital costs were significantly higher for sickle cell trait patients ($9,610 vs $8,075) and length of stay was longer (4.2 vs 3.8 days).

Cite This Study

Amro Awad (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4a0 https://doi.org/10.1182/blood-2025-1172

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Implication

Retrospective assessment reveals sickle cell trait increases postpartum hemorrhage and acute kidney injury in pre-eclamptic women, implying greater healthcare utilization.

Maternal outcomes in sickle cell trait patients hospitalized with preeclampsia and eclampsia

Discussion

Member takes

Implication

Key Points

Cite This Study

Maternal outcomes in sickle cell trait patients hospitalized with preeclampsia and eclampsia

Discussion

Member takes

Implication

Key Points

Cite This Study

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