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December 8, 2025Blood

Demographic, neurocognitive, disease impact, and social characteristics of patients served by embedded neuropsychological services in an adult sickle cell clinic

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BBBrooke Benowitz

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Overview

Descriptive analysis reveals correlations between SDoH and cognitive performance in adults with sickle cell disease, suggesting a need for improved neuropsychological evaluation access.

Key Points

  • This research aims to explore the characteristics and correlates of social determinants of health in adults with sickle cell disease undergoing neuropsychological evaluation.
  • Descriptive statistics computed on sociodemographic and neurocognitive data from patients in an SCD clinic.
  • Multivariate analyses of variance compared cognitive performance by insurance type.
  • Pearson correlations evaluated relationships between area deprivation index, education, and SCD impact.
  • 34 adults with sickle cell disease completed neuropsychological evaluation over 8 months.
  • Cognitive performance was average, with low average scores in complex attention, processing speed, and flexible problem-solving.
  • No significant differences were found in cognitive performance by insurance status, although large effect sizes suggest potential meaningful differences.

Cite This Study

Brooke Benowitz (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4abhttps://doi.org/10.1182/blood-2025-1187
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Developmental Interconnections in Sickle Cell Disease: A Bio-Psycho-Social Model of Health from Childhood to Young Adulthood2026
  2. 2Evaluating the efficacy of brief neurocognitive assessments in adults and adolescents with sickle cell disease2025
  3. 3B - 102 Neurocognitive Functioning of Patients Diagnosed with Sickle Cell Disease in Low-to-Middle Income Countries2024
  4. 4Empirically derived profiles of neurocognitive functioning in youth and young adults with sickle cell disease2024 · 5 citations
  5. 5Description of neurocognition in adult sickle cell disease patients using the NIH toolbox2025