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December 8, 2025BloodOpen Access

Superior outcome from frontline cord blood transfusion combined HLA-full-matched unrelated donor hematopoietic stem cell transplantation for aplastic anemia

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Authors

THTonglin HuRZRui ZhengQYQinghong Yu

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Overview

Retrospective analysis shows improved outcomes in hematopoietic stem cell transplantation, indicating cord blood transfusions may enhance effectiveness and safety.

Key Points

  • To compare outcomes of umbilical cord blood transfusion combined with different stem cell transplant strategies in patients with aplastic anemia.
  • Retrospective analysis of patients receiving HSCT from January 2014 to December 2023.
  • Comparison of three groups: MUD-cord-HSCT, MSD-HSCT, and Haplo-HSCT.
  • All patients received the FCA conditioning regimen prior to transplant.
  • FM-MUD-cord-HSCT showed superior overall survival (100%) compared to Haplo-HSCT and SM-MUD-cord-HSCT.
  • MUD-cord-HSCT group had a significantly lower incidence of mixed chimerism compared to MSD-HSCT (0% vs. 24.48%).
  • Lower rates of grade II–IV acute GVHD observed in FM-MUD-cord-HSCT compared to other groups.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e533https://doi.org/10.1182/blood-2025-2512
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