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December 10, 2025Asian Journal of Organic Chemistry

Diastereoselective Three‐Component Annulation for the Synthesis of Sulfonylated Polycyclic Indolines

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Authors

XZXiangyun ZhengYXYingying XuXTXiangtu Tu

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Overview

Radical relay reaction achieved high yields in sulfonylated polycyclic indolines, suggesting reduced catalyst reliance.

Key Points

  • This research aims to develop a three-component reaction for synthesizing sulfonylated polycyclic indolines.
  • Conducted a radical relay reaction without additives and metal catalysts.
  • Employed mild reaction conditions that do not require high temperatures.
  • Analyzed diastereoselectivity with a focus on a 1,5-HAT mechanism.
  • Achieved moderate to excellent yields of sulfonylated polycyclic indolines.
  • Demonstrated exceptional diastereoselectivity with a ratio greater than 20:1.
  • Eliminated the necessity for transition metal catalysts in the synthesis.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/69401d472d562116f28f856dhttps://doi.org/10.1002/ajoc.70284
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