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June 28, 2026The Journal of Organic Chemistry

A Catalyst-Free Three-Component Approach to Sulfonated Indole-Fused Diazepinones via SO 2 Insertion

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Authors

JJJiayi JiangMZM ZhangSHShuping Huang

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Overview

Randomized trial establishes a green method for synthesizing sulfonated diazepinones, indicating environmental benefits.

Key Points

  • This research aims to develop an environmentally friendly method for producing sulfonated indole-fused diazepinones.
  • Utilized a catalyst-free multicomponent radical annulation approach.
  • Applied mild reaction conditions to accommodate a broad substrate scope.
  • Achieved high yields and excellent diastereoselectivity in the synthesis process.
  • Produced sulfonated indole-fused diazepinones with yields exceeding 99%.
  • Achieved diastereoselectivity ratios of up to 20:1 in favor of one isomer.
  • Demonstrated a successful green chemistry approach without catalysts.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6a40b92b61bb0a67205c580chttps://doi.org/10.1021/acs.joc.6c00829
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