Formulating of moringa oil microemulsion used Surfactant Poly Ethylene Glycol 40 Hydrogenated Castrol Oil and Co-Surfactant of Glycerin

Moringa seed oil contains oleic acid that benefits the skin. It has anti-inflammatory and skin moisturizing properties. Increasing effectiveness: Moringa oil is made into a microemulsion. The microemulsion system consists of Moringa oil, S-mix (Polyethylene Glycol 40 Hydrogenated Castor Oil as a surfactant and glycerine as a co-surfactant), and water. The microemulsions are formulated by a titration method and create a pseudo ternary phase diagram with S-mix (Surfactant: Co-surfactant) at 3:2, 1:1, and 2:3. The most optimized moringa oil microemulsion formulation was subjected to characterized such as organoleptic properties, %Transmittance, pH, viscosity, stability, particle globule size, zeta potential, and polydispersity index (PdI). The construction of a pseudo-ternary phase diagram and the titration methods constituted a suitable technique for preparing microemulsions, as most formulations were transparent. It was found that S-Mix (1:1) has a broad area with the oil phase in the range of 4.0% - 8.3%, S-Mix in the range of 48.0%-66.7%, and water in the field of 25.0-48%. The pH is in the range of 5.91-7.64. Meanwhile, the viscosity is in the range of 60-992cPs. The decline in oil and S-mix concentration reduces the pH value and viscosity. They are stable after the thermodynamic test, freeze-thaw cycling test, and after being kept at room temperature for one month. According to these findings, the microemulsion of moringa oil using PEG 40 Hydrogenated Castor Oil and Glycerine formulation might serve as a suitable drug delivery system.