Key result
Baseline LV dyssynchrony, particularly involving the posterior papillary muscle, is associated with improved mitral regurgitation post-cardiac resynchronization therapy.
Why the study?
Does cardiac resynchronization therapy improve mitral regurgitation in patients with baseline LV dyssynchrony?
Does cardiac resynchronization therapy improve mitral regurgitation in patients with baseline LV dyssynchrony?
The anatomical location of baseline LV dyssynchrony determines whether improvement in mitral regurgitation after CRT is immediate or delayed.
May inform pre-CRT dyssynchrony assessment for MR response; extends observational data but leaves practice change open pending RCTs.
Current data suggest that the presence of baseline LV dyssynchrony is related to improvement in MR after CRT. LV dyssynchrony involving the posterior papillary muscle may lead to an immediate reduction in MR, whereas LV dyssynchrony in the lateral wall resulted in late response to CRT.
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Ypenburg et al. (2008) studied this question. Baseline LV dyssynchrony, particularly involving the posterior papillary muscle, is associated with improved mitral regurgitation post-cardiac resynchronization therapy.
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