What does this research mean for the field?

CT coronary perfusion territory analysis effectively predicts ablation volume for PTSMA, with significant reductions in LVOT-PG of 67.9 to 12.5 mmHg (P<0.001). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the capability of CT perfusion territory analysis in predicting ablation volume for PTSMA in patients with HOCM.

February 8, 2026European Heart Journal

The usefulness of coronary CT angiography-based perfusion territory analysis for PTSMA

Q: What are the key findings of this study?

Coronary CT perfusion territory analysis predicted ablation volume correlating with MRI edema (r=0.635) and CPK (r=0.711) in PTSMA patients, aiding procedural planning.

Q: What question did this study set out to answer?

To assess the capability of CT perfusion territory analysis in predicting ablation volume for PTSMA in patients with HOCM.

View Full Paper

Ask AI

Bookmark

Key result

Coronary CT perfusion analysis predicts ablation volume and correlates with MRI edema to aid PTSMA planning.

Why the study?

Does coronary CT angiography-based perfusion territory analysis predict ablation volume in patients with hypertrophic obstructive cardiomyopathy undergoing percutaneous transluminal septal myocardial ablation?

Population

22 HOCM patients with successful PTSMA

Design

Retrospective study

Authors

KTK TashiroNiigata University RIRyutaro IkegamiNiigata University YWYuzo WashiyamaMie University Hospital

Discussion

Member takes

Implication

May aid PTSMA branch selection in HOCM; extends CT utility but leaves open prospective outcome impact.

Key Points

To assess the capability of CT perfusion territory analysis in predicting ablation volume for PTSMA in patients with HOCM.
Retrospective evaluation of 22 HOCM patients undergoing PTSMA.
Pre-procedural coronary CT angiography used to analyze septal branch perfusion territories.
Follow-up cardiac MRI assessed myocardial edema volume post-procedure.
PTSMA significantly decreased LVOT-PG from 67.9 to 12.5 mmHg; P<0.001.
BNP levels reduced from 152.1 to 97.8 pg/mL; P<0.001.
CT perfusion volume correlated with MRI-measured myocardial edema volume (r=0.635; P=0.0035).
CT perfusion volume showed a strong correlation with peak CPK (r=0.711; P<0.001).
Multiple-branch ablation cases had smaller perfusion volume per septal branch than single-branch cases (7.7±2.5 vs 13.5±2.7 ml; P=0.003).

Structured PICO

Population

22 patients with hypertrophic obstructive cardiomyopathy (HOCM) who underwent successful percutaneous transluminal septal myocardial ablation (PTSMA) and had pre-procedural coronary CT.

Intervention

Coronary CT angiography-based perfusion territory analysis prior to percutaneous transluminal septal myocardial ablation (PTSMA).

Outcome

Correlation between CT-derived perfusion volume and MRI-measured myocardial edema volume or peak CPK.surrogate

Pre-procedural coronary CT angiography perfusion territory analysis correlates with post-procedural myocardial edema and peak CPK, suggesting its utility in predicting ablation volume and guiding septal branch selection for PTSMA.

Cite This Study

Tashiro et al. (2025) studied this question. Coronary CT perfusion territory analysis predicted ablation volume correlating with MRI edema (r=0.635) and CPK (r=0.711) in PTSMA patients, aiding procedural planning.

synapsesocial.com/papers/698828eb0fc35cd7a8848c2b https://doi.org/10.1093/eurheartj/ehaf784.153

Topics

Hypertrophic cardiomyopathy HFrEF treatment Heart failure Coronary CT angiography AF ablation outcomes

View Full Paper

Ask AI

Bookmark

The usefulness of coronary CT angiography-based perfusion territory analysis for PTSMA

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

The usefulness of coronary CT angiography-based perfusion territory analysis for PTSMA

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider