PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 8, 2026European Heart Journal0 citations

Global Area Strain Assessment of Left Ventricular Function in Hypertensive Pregnancy

The importance of global area strain in the assessment of the left ventricular systolic function in hypertensive pregnancy

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does global area strain (GAS) detect differences in left ventricular systolic function between normotensive and hypertensive pregnant women?

Population

121 pregnant women in the third trimester

Comparison

3D echocardiographic assessment of Global Area… vs Normotensive pregnant women

Design

Cohort

Follow-up

Two months after delivery

Key result

Hypertensive pregnant women had significantly lower global area strain (GAS) values (-28.00 GH, -26.90 PE) versus controls (-32.80), persisting postpartum (p < 0.001).

Authors

AIA IlicSSSnežana StojšićMSM Stefanovic

Discussion

Loading...

Member takes

Overview

GAS detects subclinical LV systolic impairment in hypertensive pregnancies persisting postpartum; hypothesis-generating for risk stratification.

Key Points

  • The aim is to evaluate differences in left ventricular systolic function in hypertensive and normotensive pregnant women using global area strain.
  • Prospective inclusion of 121 pregnant women: 26 normotensive, 49 with gestational hypertension (GH), and 46 with preeclampsia (PE).
  • Conducted complete clinical and echocardiographic exams, including 24-hour ambulatory blood pressure monitoring during the third trimester and postpartum.
  • Postpartum assessments excluded women who did not become normotensive.
  • Significant differences in global area strain (GAS) values among groups: controls (-32.80), GH (-28.00), and PE (-26.90), p < 0.001.
  • Two months postpartum, GAS values improved but remained lower for women with GH and PE compared to normotensive controls (p < 0.001).
  • No significant difference in GAS values postpartum between women with GH and PE (p = 0.103).

Structured PICO

Does global area strain (GAS) detect differences in left ventricular systolic function between normotensive and hypertensive pregnant women?

P
Population
121 pregnant women in the third trimester (26 normotensive controls, 49 with gestational hypertension, 46 with preeclampsia)
I
Intervention
3D echocardiographic assessment of Global Area Strain (GAS)
C
Comparator
Normotensive pregnant women
O
Outcome
Left ventricular systolic function assessed by Global Area Strain (GAS) in the third trimester and two months postpartumsurrogate

Hypertensive pregnant women have significantly worse left ventricular systolic function assessed by global area strain compared to normotensive pregnant women, which persists two months postpartum.

Cite This Study

Ilic et al. (2025) studied this question. Hypertensive pregnant women had significantly lower global area strain (GAS) values (-28.00 GH, -26.90 PE) versus controls (-32.80), persisting postpartum (p < 0.001).

synapsesocial.com/papers/6988290a0fc35cd7a8849046https://doi.org/10.1093/eurheartj/ehaf784.4166
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Ventricular Function in Gestational Hypertension: Serial Echocardiographic Study2009 · 26 citations
  2. 2Prognostic Effect of Left Atrial Function by Three‐Dimensional Speckle‐Tracking Echocardiography on Adverse Pregnancy Outcomes in Patients With Hypertensive Disorders of Pregnancy: A Preliminary Study2025
  3. 3Left atrial phasic function in gestational hypertension2019
  4. 4Assessment of cardiac hemodynamic changes during pregnancy in normal and hypertensive women2018
  5. 5Impact of Three-Dimensional Assessment of Maternal Left Ventricular Systolic Function on Pregnancy Outcomes2025 · 1 citations