Key result
Non-insulin-based insulin resistance indices linked to higher pre-HTN risk.
Why the study?
Are non-insulin-based indices of insulin resistance associated with a higher risk of pre-hypertension?
Are non-insulin-based indices of insulin resistance associated with a higher risk of pre-hypertension?
Non-insulin-based indices of insulin resistance are associated with pre-hypertension and could serve as cost-effective tools for early detection, though prospective studies are needed to establish causality.
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May inform pre-hypertension risk stratification; leaves open causality and requires prospective validation before practice change.
This meta-analysis reveals that non-insulin-based IR indices are associated with a higher risk of pre-HTN. However, given the cross-sectional design of all included studies, a causal relationship cannot be inferred. As cost-effective and user-friendly tools, they could aid in the early detection and prevention of HTN, but further prospective and longitudinal research is needed to confirm these findings and establish causality.
Farahmand et al. (2026) studied this question. Non-insulin-based insulin resistance indices are associated with an increased risk of pre-hypertension, but causality has not been established.
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