Key result
Immobilization of the S4 segment of the second domain of sodium channels prevents channel opening, indicating distinct roles of voltage sensors in gating.
Population
Voltage-gated ion channels (sodium and Shaker potassium channels)
Design
Preclinical
Authors
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Preclinical data warrant no practice change; extends models of distinct voltage sensor roles in Na channel gating.
Specific voltage sensors of the sodium channel play unique roles in gating, suggesting that movement of the domain 4 S4 segment is a multi-step process coupled to different gates.
Horn et al. (2000) studied this question. Immobilization of the S4 segment of the second domain of sodium channels prevents channel opening, indicating distinct roles of voltage sensors in gating.
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