What question did this study set out to answer?

This research aims to explore new immunization methods to elicit broadly neutralizing antibodies against HIV-1.

February 16, 2026

Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization.

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This research aims to explore new immunization methods to elicit broadly neutralizing antibodies against HIV-1.
Created a knockin mouse model with B cells for a specific bnAb lineage.
Administered a single injection of a germline-targeting trimer to test antibody development.
Utilized primate and mouse models in combination with structural analysis.
Antibodies showed neutralization capacity against various HIV-1 strains.
Single immunization recapitulated the development of mature bnAbs in the mouse model.
Boosting with escape mutant trimers enhanced antibody breadth and potency.

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Implication

Experiment reveals antibodies from a single immunization block simian-human immunodeficiency virus, suggesting innovative immunization strategies for HIV.

Cite This Study

Ghosh et al. (2026) studied this question.

synapsesocial.com/papers/699264d1eb1f82dc367a0abc https://doi.org/10.1126/sciimmunol.adz5064

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Implication

Experiment reveals antibodies from a single immunization block simian-human immunodeficiency virus, suggesting innovative immunization strategies for HIV.

Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization.

Key Points

Discussion

Implication

Cite This Study

Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization.

Key Points

Discussion

Implication

Cite This Study

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