Key result
QiShen YiQi added to basic therapy improves 6MWD by ~20 meters in HFpEF.
Why the study?
Decreased exercise tolerance and impaired physical function in elderly patients with HFpEF impair quality of life with limited enhancement from available treatments, prompting investigation into QiShen YiQi dripping pills.
Does the addition of QiShen YiQi dripping pills to standard therapy improve 6-minute walk distance in elderly patients with HFpEF?
Population
84 elderly HFpEF patients ≥ 65 years old
Comparison
QSYQ dripping pills plus basic therapy vs basic therapy alone
Design
Open-label, evaluator-blinded randomized controlled trial
Follow-up
12 weeks
Authors
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May improve exercise tolerance in elderly HFpEF when added to standard therapy; extends limited evidence for adjunctive traditional Chinese medicine.
RCT (n=84)
Open-label, evaluator-blinded
Randomized
Does the addition of QiShen YiQi dripping pills to standard therapy improve 6-minute walk distance in elderly patients with HFpEF?
Effect estimate: Difference 20.38 meters (95% CI 1.74-39.02)
p-value: p=0.035
The addition of QiShen YiQi dripping pills to standard therapy may improve exercise tolerance and physical function in elderly patients with HFpEF over 12 weeks.
Li et al. (2026) conducted an RCT in Heart failure with preserved ejection fraction (HFpEF) (n=84). QiShen YiQi (QSYQ) dripping pills vs. Basic HFpEF therapy was evaluated on 6-minute walk distance (6MWD) at 12 weeks (Difference 20.38 meters, 95% CI 1.74-39.02, p=0.035). QiShen YiQi dripping pills combined with basic therapy significantly improved 6-minute walk distance compared to basic therapy alone (difference 20.38 meters; 95% CI 1.74-39.02; P=0.035).
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