What question did this study set out to answer?

To analyze the relationship between shoulder joint radiation dose and patient-reported arm morbidity after surgery in breast cancer patients.

February 23, 2026Radiotherapy and OncologyOpen Access

Association between shoulder joint radiation dose and arm morbidity in the randomized breast cancer trial SENOMAC

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To analyze the relationship between shoulder joint radiation dose and patient-reported arm morbidity after surgery in breast cancer patients.
Participants included 868 Swedish patients from the SENOMAC trial
Patients randomized to either sentinel lymph node biopsy or axillary lymph node dissection
Radiation dose assessed using radiotherapy plans
Arm morbidity evaluated with the Lymph-ICF questionnaire
Data collected for a follow-up period of three years.
Higher maximum radiation dose linked to worse arm morbidity in patients with breast-conserving surgery
No significant dose-symptom association found in axillary dissection group
No dose thresholds for arm-related side effects could be identified
Extended follow-up may provide clearer insights into chronic shoulder morbidity.

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Implication

Randomized trial associates higher radiation dose with increased arm morbidity in breast cancer patients, indicating the need for revised dose guidelines.

Cite This Study

Alkner et al. (2026) studied this question.

synapsesocial.com/papers/699b9eefcdd3ba3e8975b6f7 https://doi.org/10.1016/j.radonc.2026.111454

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Implication

Randomized trial associates higher radiation dose with increased arm morbidity in breast cancer patients, indicating the need for revised dose guidelines.

Association between shoulder joint radiation dose and arm morbidity in the randomized breast cancer trial SENOMAC

Key Points

Discussion

Implication

Cite This Study

Association between shoulder joint radiation dose and arm morbidity in the randomized breast cancer trial SENOMAC

Key Points

Discussion

Implication

Cite This Study

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