What question did this study set out to answer?

This research aims to understand how different tissue environments influence the clonal selection and differentiation of CD4+ T cells during infection.

February 24, 2026Open Access

Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection

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This research aims to understand how different tissue environments influence the clonal selection and differentiation of CD4+ T cells during infection.
Generated TRACK mice for tracking recently activated CD4+ T cells.
Performed T cell receptor sequencing to analyze clonal identity.
Assessed clonal selection in the lungs, mediastinal lymph nodes, and spleen during influenza infection.
Observed organ-specific clonal selection and transcriptional differentiation in various tissues.
Identified low clonal overlap between tissues during acute infection.
Spleen-derived CD4+ T cells displayed a stem-like migratory phenotype, while medLN cells became T follicular helper cells.
Memory CD4+ T cells showed increased clonal overlap across tissues over time.

Authors

RPRoham Parsa HAHelder Luiz Taveira de [UNESP] AssisUniversidade Estadual de Campinas (UNICAMP)TCTiago Bruno de CastroRockefeller University

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Implication

This research demonstrates tissue-dependent clonal selection and differentiation of CD4+ T cells during infection, indicating complex immune responses.

Cite This Study

Parsa et al. (2026) studied this question.

synapsesocial.com/papers/699d401ade8e28729cf65146 https://doi.org/10.5281/zenodo.18726876

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Implication

This research demonstrates tissue-dependent clonal selection and differentiation of CD4+ T cells during infection, indicating complex immune responses.

Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection

Key Points

Discussion

Implication

Cite This Study

Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection

Key Points

Discussion

Implication

Cite This Study

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