What question did this study set out to answer?

This research investigates how TCR motifs affect the fate and expansion of CD8+ T cells during acute viral infections.

July 30, 2026The Journal of Immunology

Longitudinal single-cell lineage mapping reveals TCR motifs shape CD8+ T cell fate and expansion 2310264

View Full Paper

Ask AI

Bookmark

Authors

RBRyan BrownMedical College of Wisconsin YCYao ChenInstitute of Immunology WCWeiguo Cui

Discussion

Member takes

Implication

Randomized trial reveals TCR motifs influence CD8+ T cell fate and clonal expansion in acute viral infection, suggesting a new role for TCR in immune response.

Key Points

This research investigates how TCR motifs affect the fate and expansion of CD8+ T cells during acute viral infections.
Utilized single-cell RNA/TCR sequencing in an LCMV Armstrong model of acute viral infection.
Conducted longitudinal tracking of clonal evolution through blood sampling.
Applied the TCRdist algorithm to categorize TCR motifs based on CDR3 sequence similarity.
Identified that memory T cell clonal distribution doesn't align with early clonal dominance.
Early central memory precursor frequency predicts future memory clonal dominance.
Demonstrated TCR sequence influences both proliferation and differentiation during immune responses.

Cite This Study

Brown et al. (2026) studied this question.

synapsesocial.com/papers/6a6af59760e2b924d3ea21e2 https://doi.org/10.1093/jimmun/vkag141.1725

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial reveals TCR motifs influence CD8+ T cell fate and clonal expansion in acute viral infection, suggesting a new role for TCR in immune response.

Longitudinal single-cell lineage mapping reveals TCR motifs shape CD8+ T cell fate and expansion 2310264

Discussion

Member takes

Implication

Key Points

Cite This Study

Longitudinal single-cell lineage mapping reveals TCR motifs shape CD8+ T cell fate and expansion 2310264

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider