What question did this study set out to answer?

This research aims to trace the clonal evolution of CD8+ T cells during an acute viral infection using single-cell techniques.

November 25, 2025The Journal of ImmunologyOpen Access

Longitudinal single-cell lineage mapping of a tetramer-specific CD8+ T cell repertoire during an acute infection 4481

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Authors

RBRyan J Brown YCYao Chen JAJohn Attanasio

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Implication

Longitudinal analysis of CD8+ T cell clonal evolution in infection shows blood samples can track lineage changes, highlighting tetramer-specific responses.

Key Points

This research aims to trace the clonal evolution of CD8+ T cells during an acute viral infection using single-cell techniques.
Used single-cell RNA and TCR sequencing in an acute LCMV Armstrong model.
Tracked clonal evolution through blood sampling.
Analyzed TCR sequence variations and established motifs using the TCRdist algorithm.
Found clonal distributions in blood reflect those in spleen and lymph nodes.
Early clonal dominance weakly predicts memory clonal dominance.
Identified that central memory precursor frequency better predicts memory clonal dominance.

Cite This Study

Brown et al. (2025) studied this question.

synapsesocial.com/papers/692502a487af00ed34ac195d https://doi.org/10.1093/jimmun/vkaf283.2158

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Implication

Longitudinal analysis of CD8+ T cell clonal evolution in infection shows blood samples can track lineage changes, highlighting tetramer-specific responses.

Longitudinal single-cell lineage mapping of a tetramer-specific CD8+ T cell repertoire during an acute infection 4481

Discussion

Member takes

Implication

Key Points

Cite This Study

Longitudinal single-cell lineage mapping of a tetramer-specific CD8+ T cell repertoire during an acute infection 4481

Discussion

Member takes

Implication

Key Points

Cite This Study

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