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September 5, 2025Open Access

Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection

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Authors

RPRoham ParsaChan Zuckerberg Biohub San Francisco HAHelder Carvalho de AssisRockefeller University TCTiago B. R. CastroRockefeller University

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Implication

Findings reveal organ-specific clonal selection and differentiation of CD4+ T cells during influenza infection, indicating distinct tissue environments influence immune responses.

Key Points

Distinct tissue environments drive clonal selection and differentiation of CD4+ T cells during infection.
TRACK mice analysis showed local antigenic landscapes shape T cell receptor diversity in tissues.
Memory CD4+ T cells exhibit converging antigen specificity across tissues over time.
Spleen-derived CD4+ T cells adopt a migratory phenotype, while medLN cells differentiate into T follicular helper cells.

Cite This Study

Parsa et al. (2025) studied this question.

synapsesocial.com/papers/68bb421a2b87ece8dc9587ef https://doi.org/10.1101/2025.08.25.672130

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Implication

Findings reveal organ-specific clonal selection and differentiation of CD4+ T cells during influenza infection, indicating distinct tissue environments influence immune responses.

Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection

Discussion

Member takes

Implication

Key Points

Cite This Study

Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection

Discussion

Member takes

Implication

Key Points

Cite This Study

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