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February 28, 2026PLoS ONEOpen Access

Designing a novel vaccine against COVID-19 based on spike SARS-Cov-2 notable mutations using immunoinformatics approaches

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Authors

SRSomayyeh RahimnahalSYShahnaz YousefizadehYMYahya Sayed Mohammadi

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Overview

Immunoinformatics approaches design multi-epitope vaccines targeting spike mutations in COVID-19 variants, indicating potential for broad immunity.

Key Points

  • The aim is to design vaccine constructs that target notable spike protein mutations in SARS-CoV-2 variants using immunoinformatics methods.
  • Used sequence data from NCBI, GISAID, and UniProt to identify epitopes.
  • Designed two multi-epitope vaccine constructs with selected high-antigenicity epitopes.
  • Enhanced constructs with various adjuvants and structural linkers for stability.
  • Performed computational analyses including molecular docking and immune simulations for validation.
  • Constructs achieved high global population coverage with epitopes (76.83% for MHC I, 87.43% for MHC II).
  • Molecular docking indicated stable interactions with human neutralizing antibodies.
  • Immune simulations demonstrated the constructs triggered strong humoral and cellular responses.

Cite This Study

Rahimnahal et al. (2026) studied this question.

synapsesocial.com/papers/69a287010a974eb0d3c024efhttps://doi.org/10.1371/journal.pone.0334662
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