What does this research mean for the field?

Patients with newly diagnosed multiple myeloma who have cardiac disease and are smokers are at higher risk of developing infections early in their treatment course and may benefit from tailored antimicrobial prophylaxis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 28, 2026Cancer Treatment and Research CommunicationsOpen Access

Assessment of Bacterial Infection Risk Factors and Related Complications in Newly Diagnosed Multiple Myeloma: A Retrospective Cohort Analysis

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Authors

MAMaha AlDoughaimKing Saud bin Abdulaziz University for Health Sciences MAMohammed AlZahraniKing Saud bin Abdulaziz University for Health Sciences AAAtheer AldairemKing Saud bin Abdulaziz University for Health Sciences

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Implication

Retrospective analysis reveals cardiac disease and smoking increase infection risk in multiple myeloma, highlighting the need for tailored interventions.

Key Points

The aim is to assess bacterial infection risk factors and related complications in newly diagnosed multiple myeloma patients.
Retrospective chart review of patients treated for multiple myeloma at a cancer center from 2015 to 2023
Primary endpoint assessed bacterial infection risk factors within the first 6 months of diagnosis
Secondary endpoints evaluated infection-related hospitalizations, mortality rate, and resistance patterns of bacterial isolates
Multivariable logistic regression analyzed predictors of infection
Cox proportional hazards regression assessed predictors of mortality.
Cardiac disease and smoking significantly increased the risk of bacterial infections
Patients with infections had an average hospital stay of 7.7 days
Around 10% of deaths occurred within the first year of diagnosis, with cardiac disease as a mortality predictor
Approximately 25% of bacterial isolates were multidrug-resistant, primarily from urine samples
50% of patients had high-risk features at diagnosis.

Cite This Study

AlDoughaim et al. (2026) studied this question.

synapsesocial.com/papers/69a2878e0a974eb0d3c034cc https://doi.org/10.1016/j.ctarc.2026.101158

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Implication

Retrospective analysis reveals cardiac disease and smoking increase infection risk in multiple myeloma, highlighting the need for tailored interventions.

Assessment of Bacterial Infection Risk Factors and Related Complications in Newly Diagnosed Multiple Myeloma: A Retrospective Cohort Analysis

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Key Points

Cite This Study

Assessment of Bacterial Infection Risk Factors and Related Complications in Newly Diagnosed Multiple Myeloma: A Retrospective Cohort Analysis

Discussion

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Implication

Key Points

Cite This Study

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