Therapeutic Lymphangiogenesis Using Induced Cardiac Fibroblasts Protects the Heart From Heart Failure With Preserved Ejection Fraction Progression by Exerting Anti-Inflammatory and Antifibrotic Effects

Haihang Luo; Yuuki Shimizu; Takahiro Iwamiya; Yuimi Matsuoka; Xiyu Chen; Tianyu Liu; Yiyang Che; Takumi Hayashi; Zhongyue Pu; Shukuro Yamaguchi; Koji Sakamoto; Toyoaki Murohara

doi:10.1253/circj.cj-25-0757

January 27, 2026Circulation JournalOpen Access

Therapeutic Lymphangiogenesis Using Induced Cardiac Fibroblasts Protects the Heart From Heart Failure With Preserved Ejection Fraction Progression by Exerting Anti-Inflammatory and Antifibrotic Effects

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Key Points

Heart failure with preserved ejection fraction can be mitigated through therapeutic lymphangiogenesis, potentially halting disease progression.
The study highlights the role of cardiac fibroblasts in exerting anti-inflammatory and antifibrotic effects during this process.
Assessment involved understanding the remodeling and function of cardiac lymphatic vessels in heart failure progression.
These findings may indicate a promising therapeutic avenue for heart failure treatment, but further studies are warranted.

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Implication

Observational analysis reveals lymphangiogenesis mitigates heart failure progression, suggesting a new treatment target.

Abstract

Cardiac lymphatic vessels play an important role in remodeling and function in HFpEF progression. Moreover, lymphangiogenesis could be a novel therapeutic target for HFpEF.

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Luo et al. (2026) studied this question.

synapsesocial.com/papers/69a75b1dc6e9836116a21d65 https://doi.org/10.1253/circj.cj-25-0757

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Therapeutic Lymphangiogenesis Using Induced Cardiac Fibroblasts Protects the Heart From Heart Failure With Preserved Ejection Fraction Progression by Exerting Anti-Inflammatory and Antifibrotic Effects

Key Points

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Implication

Abstract

Discussion

Cite This Study

Therapeutic Lymphangiogenesis Using Induced Cardiac Fibroblasts Protects the Heart From Heart Failure With Preserved Ejection Fraction Progression by Exerting Anti-Inflammatory and Antifibrotic Effects

Key Points

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Implication

Abstract

Discussion

Cite This Study

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