A bioinspired, pH-responsive microsphere matrix of cold-water extracted Colocasia esculenta mucilage and alginate: a new approach for sustained oral delivery of tramadol

Shazia Noureen; Sobia Noreen; Fozia Batool; Shazia Akram Ghumman; Sara Hasan; Samina Aslam; Nisar Ahmed

doi:10.1039/d5pm00263j

January 1, 2026RSC PharmaceuticsOpen Access

A bioinspired, pH-responsive microsphere matrix of cold-water extracted Colocasia esculenta mucilage and alginate: a new approach for sustained oral delivery of tramadol

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Key Points

The new microsphere matrix effectively enhances oral delivery of tramadol with sustained release.
Key evidence shows that this system delays tramadol release significantly when exposed to varying pH levels.
Assessment uses a bioinspired strategy employing natural polymers like mucilage and alginate for drug formulation.
This advancement supports broader applications in drug delivery, specifically utilizing plant-derived materials.

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Implication

Observational analysis reveals a new pH-responsive microsphere approach for tramadol delivery, highlighting potential advancements in drug delivery systems.

Abstract

Natural polymers derived from plant mucilages are increasingly explored as release-modifying agents in advanced drug delivery systems.

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Noureen et al. (2026) studied this question.

synapsesocial.com/papers/69a75be8c6e9836116a24170 https://doi.org/10.1039/d5pm00263j

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A bioinspired, pH-responsive microsphere matrix of cold-water extracted Colocasia esculenta mucilage and alginate: a new approach for sustained oral delivery of tramadol

Key Points

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Implication

Abstract

Discussion

Cite This Study

A bioinspired, pH-responsive microsphere matrix of cold-water extracted Colocasia esculenta mucilage and alginate: a new approach for sustained oral delivery of tramadol

Key Points

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Implication

Abstract

Discussion

Cite This Study

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