A bioinspired, pH-responsive microsphere matrix of cold-water extracted Colocasia esculenta mucilage and alginate: a new approach for sustained oral delivery of tramadol

Key Points

• The new microsphere matrix effectively enhances oral delivery of tramadol with sustained release.
• Key evidence shows that this system delays tramadol release significantly when exposed to varying pH levels.
• Assessment uses a bioinspired strategy employing natural polymers like mucilage and alginate for drug formulation.
• This advancement supports broader applications in drug delivery, specifically utilizing plant-derived materials.